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Effect of ultraviolet irradiation and chlorination on ampicillin-resistant

Yuchen PANG,Jingjing HUANG,Jinying XI,Hongying HU,Yun ZHU

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 3,   Pages 522-530 doi: 10.1007/s11783-015-0779-9

Abstract: Ampicillin is a widely prescribed antibiotic but its effectiveness is increasingly undermined by resistanceIn this study, changes in ampicillin resistance for ( ) CGMCC 1.1595 were analyzed after exposure toresistance gene was assessed.when subsequently exposed to ampicillin.resistance.

Keywords： antibiotic resistance     Escherichia coli     ampicillin resistance gene     ultraviolet irradiation     chlorination    

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Assessment of antibiotic resistance genes in dialysis water treatment processes

Xuan Zhu, Chengsong Ye, Yuxin Wang, Lihua Chen, Lin Feng

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1136-1

Abstract:

• Quantitative global ARGs profile in dialysis water was investigated.

• Totally 35 ARGs were found in the dialysis treatment train.

• 29 ARGs (highest) were found in carbon filtration effluent.

• erm and mtrD-02 occurred in the final effluent.

• The effluent was associated with health risks even after RO treatment.

Keywords： Dialysis water     Treatment process     Antibiotic resistance gene     High-throughput quantitative PCR     Horizontalgene transfer    

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The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 161-168 doi: 10.1007/s11684-017-0531-x

Abstract:

The antibiotic resistance is natural in bacteria and predates the human use of antibiotics.Numerous antibiotic resistance genes (ARGs) have been discovered to confer resistance to a wide rangeWe propose that the resistance gene flow in nature is “from the natural environments” andrdquo;; human and animals, as intermediate recipients and disseminators, contribute greatly to such a resistancegene “circulation.

Keywords： antibiotic resistance     resistome     microbiome     gene flow    

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Distribution and removal of antibiotic resistance genes during anaerobic sludge digestion with alkaline

Mengli Wang, Ruying Li, Qing Zhao

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1127-2

Abstract:

The total ARGs concentration showed significant correlation with 16S rRNA gene

Keywords： Tetracycline resistance genes     Sulfonamide resistance genes     16S rRNA gene     Sludge pretreatment     Anaerobic    

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Bacteriophages in water pollution control: Advantages and limitations

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 5, doi: 10.1007/s11783-020-1378-y

Abstract:

•Phages can be better indicators of enteric viruses than fecal indicator bacteria.

Keywords： Phage     Water pollution monitoring     Harmful bacteria biocontrol     Horizontal gene transfer     Bacterial resistance    

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Mitigating microbiological risks of potential pathogens carrying antibiotic resistance genes and virulence

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 7, doi: 10.1007/s11783-023-1682-4

Abstract:

● Abundance of MAGs carrying ARG-VF pairs unchanged in rivers after WWTP upgrade.

Keywords： Wastewater treatment plant upgrade     Antibiotic resistance genes (ARGs)     Virulence factors (VFs)     Gene    

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Identification of molecular markers linked to rice bacterial blight resistance genes from

Jing WANG,Chen CHENG,Yanru ZHOU,Yong YANG,Qiong MEI,Junmin LI,Ye CHENG,Chengqi YAN,Jianping CHEN

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 3,   Pages 260-265 doi: 10.15302/J-FASE-2015070

Abstract: showed that Y73 had inherited a high level of resistance to rice bacterial blight (BB) from its wildMolecular markers linked to the BB resistance genes in Y73 were scanned using the F population and theR03D159 on chromosome 3 and the STS marker R05D104 on chromosome 5 were found to be linked to the rice BB resistance

Keywords： Oryza meyeriana     bacterial blight resistance gene     genetic population     linkage molecular marker    

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Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 269-273 doi: 10.1007/s11684-007-0051-1

Abstract: The aim of this article was to investigate the influence and the related mechanism of the gene on glucoseuptake and insulin resistance in 3T3-L1 cells.Radioimmunoassay was used to determine glucose uptake in 3T3-L1 cells with different gene expressionto determine the mRNA levels of several glucose transport proteins in 3T3-L1 cells with different geneResistin could induce insulin resistance in adipocytes, which might be related to the changes of some

Keywords： 3T3-L1     influence     resistance     receptor substrate-1     transport    

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Biofiltration and disinfection codetermine the bacterial antibiotic resistome in drinking water: A review and meta-analysis

Kun Wan, Wenfang Lin, Shuai Zhu, Shenghua Zhang, Xin Yu

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 1, doi: 10.1007/s11783-019-1189-1

Abstract: We extracted the antibiotic resistance gene (ARG) data from recent publications and analyzed ARG profiles

Keywords： Drinking water treatment     Antibiotic resistance gene     Biofiltration     Chlorination    

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ARGs-OAP v3.0: Antibiotic-Resistance Gene Database Curation and Analysis Pipeline Optimization Article

Xiaole Yin, Xiawan Zheng, Liguan Li, An-Ni Zhang, Xiao-Tao Jiang, Tong Zhang

Engineering 2023, Volume 27, Issue 8,   Pages 234-241 doi: 10.1016/j.eng.2022.10.011

Abstract:

Antibiotic resistance, which is encoded by antibiotic-resistance genesSARG has been enhanced with sequence curation to improve annotation reliability, incorporate emerging resistance

Keywords： SARG database ARGs-OAP     Antibiotic-resistance genes     Environmental metagenome     Quantification    

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Association between the Phenotypes and Genotypes of Antimicrobial Resistance in Haemophilus parasuis Article

Chao Nguyen Van, Lijun Zhang, Tam Vu Thi Thanh, Hung Pham Hoang Son, Tuan Tran Ngoc, Qi Huang, Rui Zhou

Engineering 2020, Volume 6, Issue 1,   Pages 40-48 doi: 10.1016/j.eng.2019.10.014

Abstract: One of the reasons why the control of H. parasuis has failed is the increase in antimicrobial resistanceThe tested strains were shown to have a high frequency of resistance to trimethoprim/sulfamethoxazole(94.6%), followed by resistance to colistin, chloramphenicol, gentamicin, penicillin, lincomycin, and

Keywords： Haemophilus parasuis     Antimicrobial resistance     Antimicrobial resistance gene     Vietnam    

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Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Strategic Study of CAE 2000, Volume 2, Issue 11,   Pages 1-11

Abstract:

In this paper, the study on family collection, gene mapping, gene identification and gene functiont (1; 3) (q44; p11) associated with nasopharyngeal cancer was found in 1975 at first, and human TDF geneIn 1998, GJB3, a human genetic neurological deafness gene, was identified using a novel strategy of “Gene Family-Candidate Disease Gene Cloning”，and the paper was published in Nature Geneticswas also cloned from gene function study.

Keywords： genetic disease     gene mapping and cloning     gene familiy-candidate disease gene cloning     genome wide scan     gene function study    

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Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 663-675 doi: 10.1007/s11705-017-1623-5

Abstract: Small interfering RNA (siRNA) therapeutics hold great promise to treat a variety of diseases, as long as they can be delivered safely and effectively into cells. Dendrimers are appealing vectors for siRNA delivery by virtue of their well-defined molecular architecture and multivalent cooperativity. However, the clinical translation of RNA therapeutics mediated by dendrimer delivery is hampered by the lack of dendrimers that are of high quality to meet good manufacturing practice standard. In this context, we have developed small amphiphilic dendrimers that self-assemble into supramolecular structures, which mimic high-generation dendrimers synthesized with covalent construction, yet are easy to produce in large amount and superior quality. Indeed, the concept of supramolecular dendrimers has proved to be very promising, and has opened up a new avenue for dendrimer-mediated siRNA delivery. A series of self-assembling supramolecular dendrimers have consequently been established, some of them out-performing the currently available nonviral vectors in delivering siRNA to various cell types and , including human primary cells and stem cells. This short review presents a brief introduction to RNAi therapeutics, the obstacles to their delivery and the advantages of dendrimer delivery vectors as well as our bio-inspired structurally flexible dendrimers for siRNA delivery. We then highlight our efforts in creating self-assembling amphiphilic dendrimers to construct supramolecular dendrimer nanosystems for effective siRNA delivery as well as the related structural alterations to enhance delivery efficiency. The advent of self-assembling supramolecular dendrimer nanovectors holds great promise and heralds a new era of dendrimer-mediated delivery of RNA therapeutics in biomedical applications.

Keywords： gene therapy     RNAi therapeutics     dendrimer     nanovectors     gene silencing    

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Reflections on the system of evaluation of gene-edited livestock

Ziyao FAN, Tianwen WU, Kui WU, Yulian MU, Kui LI

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 211-217 doi: 10.15302/J-FASE-2019303

Abstract: functions regarding economic traits, and new materials for livestock breeding have been obtained through geneEvaluation is the most important component of the regulation of gene-edited livestock and is a crucialguarantee of public safety before the marketing of gene-edited animal products.Here, the system of evaluation of gene-edited livestock is discussed in terms of public safety and production

Keywords： evaluation     gene editing     livestock     performance     safety    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Then, based on RNA-seq data from The Cancer Genome Atlas AML cohort, we developed a 300-gene signatureThis study revealed the distinct gene expression pattern of RUNX1 mutations and the underlying

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Title Author Date Type Operation

Effect of ultraviolet irradiation and chlorination on ampicillin-resistant

Yuchen PANG,Jingjing HUANG,Jinying XI,Hongying HU,Yun ZHU

Journal Article

Assessment of antibiotic resistance genes in dialysis water treatment processes

Xuan Zhu, Chengsong Ye, Yuxin Wang, Lihua Chen, Lin Feng

Journal Article

The antibiotic resistome: gene flow in environments, animals and human beings

Yongfei Hu, George F. Gao, Baoli Zhu

Journal Article

Distribution and removal of antibiotic resistance genes during anaerobic sludge digestion with alkaline

Mengli Wang, Ruying Li, Qing Zhao

Journal Article

Bacteriophages in water pollution control: Advantages and limitations

Journal Article

Mitigating microbiological risks of potential pathogens carrying antibiotic resistance genes and virulence

Journal Article

Identification of molecular markers linked to rice bacterial blight resistance genes from

Jing WANG,Chen CHENG,Yanru ZHOU,Yong YANG,Qiong MEI,Junmin LI,Ye CHENG,Chengqi YAN,Jianping CHEN

Journal Article

Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Journal Article

Biofiltration and disinfection codetermine the bacterial antibiotic resistome in drinking water: A review and meta-analysis

Kun Wan, Wenfang Lin, Shuai Zhu, Shenghua Zhang, Xin Yu

Journal Article

ARGs-OAP v3.0: Antibiotic-Resistance Gene Database Curation and Analysis Pipeline Optimization

Xiaole Yin, Xiawan Zheng, Liguan Li, An-Ni Zhang, Xiao-Tao Jiang, Tong Zhang

Journal Article

Association between the Phenotypes and Genotypes of Antimicrobial Resistance in Haemophilus parasuis

Chao Nguyen Van, Lijun Zhang, Tam Vu Thi Thanh, Hung Pham Hoang Son, Tuan Tran Ngoc, Qi Huang, Rui Zhou

Journal Article

Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Journal Article

Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Journal Article

Reflections on the system of evaluation of gene-edited livestock

Ziyao FAN, Tianwen WU, Kui WU, Yulian MU, Kui LI

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation

Journal Article